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Assay Detail

CHEMBL1032540

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of lipid peroxidation in Sprague-Dawley rat heart mitochondria assessed as inhibition of FeSO4-induced malondialdehyde formation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Heart
Subcellular Mitochondria
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Effect of anthraquinone derivatives on lipid peroxidation in rat heart mitochondria: structure-activity relationship.
Huang SS, Yeh SF, Hong CY.
J Nat Prod (1995) 58 : 1365 -1371
PubMed 7494143 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.76 5.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36327 EPICATECHIN GALLATE 1 5.27
CHEMBL264938 GALLOCATECHIN GALLATE 1 5.07
CHEMBL38714 PROCYANIDIN B2 1 5.05
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 1 5.03
CHEMBL506204 PEDUNCULAGIN 1 4.92
CHEMBL289277 EMODIN 1 4.78
CHEMBL517767 1 4.38
CHEMBL55814 ATHRAQUINONES A 1 4.30
CHEMBL47 ALPHA-TOCOPHEROL 1 4.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36327 EPICATECHIN GALLATE IC50 = 5400.0 nM 5.27
CHEMBL264938 GALLOCATECHIN GALLATE IC50 = 8600.0 nM 5.07
CHEMBL38714 PROCYANIDIN B2 IC50 = 9000.0 nM 5.05
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 9400.0 nM 5.03
CHEMBL506204 PEDUNCULAGIN IC50 = 12000.0 nM 4.92
CHEMBL289277 EMODIN IC50 = 16800.0 nM 4.78
CHEMBL517767 IC50 = 42200.0 nM 4.38
CHEMBL55814 ATHRAQUINONES A IC50 = 49500.0 nM 4.30
CHEMBL47 ALPHA-TOCOPHEROL IC50 = 94700.0 nM 4.02