Assay Detail
Functional
CHEMBL1032944
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.17 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236 | DESETHYLCHLOROQUINE | — | 1 | 7.43 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 7.39 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236 | DESETHYLCHLOROQUINE | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 201.0 | nM | 6.70 |