Assay Detail
Binding
CHEMBL1033058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.63 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084515 | — | — | 1 | 8.97 |
| CHEMBL3084521 | — | — | 1 | 8.92 |
| CHEMBL3084524 | — | — | 1 | 8.85 |
| CHEMBL3084520 | — | — | 1 | 8.82 |
| CHEMBL3084519 | — | — | 1 | 8.82 |
| CHEMBL3084516 | — | — | 1 | 8.77 |
| CHEMBL3084518 | — | — | 1 | 8.31 |
| CHEMBL3084523 | — | — | 1 | 8.25 |
| CHEMBL246637 | — | — | 1 | 8.16 |
| CHEMBL445102 | — | — | 1 | 7.95 |
| CHEMBL3084522 | — | — | 1 | 7.93 |
| CHEMBL3084512 | — | — | 1 | 7.89 |
| CHEMBL3084513 | — | — | 1 | 7.53 |
| CHEMBL3084502 | — | — | 1 | 7.48 |
| CHEMBL3084503 | — | — | 1 | 7.45 |
| CHEMBL3084510 | — | — | 1 | 7.41 |
| CHEMBL3084517 | — | — | 1 | 7.40 |
| CHEMBL3084505 | — | — | 1 | 7.38 |
| CHEMBL3084506 | — | — | 1 | 6.71 |
| CHEMBL3084509 | — | — | 1 | 6.65 |
| CHEMBL3084514 | — | — | 1 | 6.55 |
| CHEMBL3084511 | — | — | 1 | 6.26 |
| CHEMBL3084504 | — | — | 1 | 6.26 |
| CHEMBL3084508 | — | — | 1 | 6.25 |
| CHEMBL3084507 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084515 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL3084521 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3084524 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL3084520 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3084519 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3084516 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3084518 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL3084523 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL246637 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL445102 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL3084522 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL3084512 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL3084513 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL3084502 | — | Ki | = | 33.4 | nM | 7.48 |
| CHEMBL3084503 | — | Ki | = | 35.3 | nM | 7.45 |
| CHEMBL3084510 | — | Ki | = | 39.4 | nM | 7.41 |
| CHEMBL3084517 | — | Ki | = | 40.1 | nM | 7.40 |
| CHEMBL3084505 | — | Ki | = | 41.4 | nM | 7.38 |
| CHEMBL3084506 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL3084509 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL3084514 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL3084511 | — | Ki | = | 554.0 | nM | 6.26 |
| CHEMBL3084504 | — | Ki | = | 545.0 | nM | 6.26 |
| CHEMBL3084508 | — | Ki | = | 565.0 | nM | 6.25 |
| CHEMBL3084507 | — | Ki | = | 2070.0 | nM | 5.68 |