Assay Detail
Binding
CHEMBL1033059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.73 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084516 | — | — | 1 | 9.47 |
| CHEMBL3084521 | — | — | 1 | 9.43 |
| CHEMBL3084524 | — | — | 1 | 9.28 |
| CHEMBL3084515 | — | — | 1 | 9.15 |
| CHEMBL3084519 | — | — | 1 | 9.04 |
| CHEMBL3084518 | — | — | 1 | 8.92 |
| CHEMBL3084523 | — | — | 1 | 8.70 |
| CHEMBL3084520 | — | — | 1 | 8.68 |
| CHEMBL3084512 | — | — | 1 | 8.44 |
| CHEMBL3084503 | — | — | 1 | 8.20 |
| CHEMBL3084522 | — | — | 1 | 8.08 |
| CHEMBL3084502 | — | — | 1 | 7.81 |
| CHEMBL3084513 | — | — | 1 | 7.75 |
| CHEMBL3084510 | — | — | 1 | 7.67 |
| CHEMBL3084505 | — | — | 1 | 7.51 |
| CHEMBL3084517 | — | — | 1 | 7.49 |
| CHEMBL3084509 | — | — | 1 | 7.07 |
| CHEMBL246637 | — | — | 1 | 6.96 |
| CHEMBL445102 | — | — | 1 | 6.79 |
| CHEMBL3084506 | — | — | 1 | 6.65 |
| CHEMBL3084514 | — | — | 1 | 6.37 |
| CHEMBL3084504 | — | — | 1 | 6.32 |
| CHEMBL3084508 | — | — | 1 | 6.27 |
| CHEMBL3084511 | — | — | 1 | 5.92 |
| CHEMBL3084507 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084516 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL3084521 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL3084524 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL3084515 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL3084519 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL3084518 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3084523 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3084520 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL3084512 | — | Ki | = | 3.62 | nM | 8.44 |
| CHEMBL3084503 | — | Ki | = | 6.35 | nM | 8.20 |
| CHEMBL3084522 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL3084502 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL3084513 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL3084510 | — | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL3084505 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3084517 | — | Ki | = | 32.2 | nM | 7.49 |
| CHEMBL3084509 | — | Ki | = | 84.7 | nM | 7.07 |
| CHEMBL246637 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL445102 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL3084506 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL3084514 | — | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL3084504 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL3084508 | — | Ki | = | 541.0 | nM | 6.27 |
| CHEMBL3084511 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL3084507 | — | Ki | = | 6410.0 | nM | 5.19 |