Assay Detail
Functional
CHEMBL1033065
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Antagonist activity at dopamine D2 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.73 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084515 | — | — | 1 | 8.72 |
| CHEMBL445102 | — | — | 1 | 8.35 |
| CHEMBL3084512 | — | — | 1 | 7.58 |
| CHEMBL3084502 | — | — | 1 | 7.32 |
| CHEMBL3084503 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084515 | — | IC50 | = | 1.92 | nM | 8.72 |
| CHEMBL445102 | — | IC50 | = | 4.46 | nM | 8.35 |
| CHEMBL3084512 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL3084502 | — | IC50 | = | 48.3 | nM | 7.32 |
| CHEMBL3084503 | — | IC50 | = | 210.0 | nM | 6.68 |