Assay Detail
Functional
CHEMBL1033066
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Antagonist activity at dopamine D3 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.08 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084515 | — | — | 1 | 9.07 |
| CHEMBL3084512 | — | — | 1 | 8.38 |
| CHEMBL3084503 | — | — | 1 | 7.99 |
| CHEMBL3084502 | — | — | 1 | 7.91 |
| CHEMBL445102 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084515 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL3084512 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3084503 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL3084502 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL445102 | — | IC50 | = | 90.4 | nM | 7.04 |