Assay Detail
Binding
CHEMBL1033171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IR
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.77 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507625 | — | — | 1 | 8.80 |
| CHEMBL464552 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507625 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL464552 | — | IC50 | = | 1.8 | nM | 8.74 |