Assay Detail
Binding
CHEMBL1033173
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Inhibition of His-tagged JNK1
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.86 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507625 | — | — | 1 | 7.89 |
| CHEMBL463116 | — | — | 1 | 7.00 |
| CHEMBL501964 | — | — | 1 | 6.90 |
| CHEMBL460815 | — | — | 1 | 6.90 |
| CHEMBL507810 | — | — | 1 | 6.60 |
| CHEMBL515036 | — | — | 1 | 6.30 |
| CHEMBL465577 | — | — | 1 | 6.20 |
| CHEMBL459753 | — | — | 1 | 6.20 |
| CHEMBL517340 | — | — | 1 | 6.10 |
| CHEMBL464551 | — | — | 1 | 6.10 |
| CHEMBL517729 | — | — | 1 | 6.00 |
| CHEMBL464757 | — | — | 1 | 6.00 |
| CHEMBL464347 | — | — | 1 | 5.90 |
| CHEMBL518354 | — | — | 1 | 5.90 |
| CHEMBL517947 | — | — | 1 | 5.90 |
| CHEMBL450919 | — | — | 1 | 5.80 |
| CHEMBL461876 | — | — | 1 | 5.80 |
| CHEMBL505915 | GSK-1751853A | — | 1 | 5.80 |
| CHEMBL511765 | GSK-2213727A | — | 1 | 5.70 |
| CHEMBL461018 | — | — | 1 | 5.70 |
| CHEMBL465168 | — | — | 1 | 5.70 |
| CHEMBL467136 | — | — | 1 | 5.60 |
| CHEMBL516816 | — | — | 1 | 5.50 |
| CHEMBL464344 | — | — | 1 | 5.50 |
| CHEMBL468619 | — | — | 1 | 5.50 |
| CHEMBL465374 | — | — | 1 | 5.41 |
| CHEMBL517171 | GSK-1713088A | — | 1 | 5.40 |
| CHEMBL461875 | — | — | 1 | 5.30 |
| CHEMBL464552 | — | — | 1 | 5.30 |
| CHEMBL516870 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507625 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL463116 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL501964 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL460815 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL507810 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL515036 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL465577 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL459753 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL517340 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL464551 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL517729 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL464757 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL464347 | — | IC50 | = | 1258.0 | nM | 5.90 |
| CHEMBL518354 | — | IC50 | = | 1258.0 | nM | 5.90 |
| CHEMBL517947 | — | IC50 | = | 1259.0 | nM | 5.90 |
| CHEMBL461876 | — | IC50 | = | 1585.0 | nM | 5.80 |
| CHEMBL450919 | — | IC50 | = | 1585.0 | nM | 5.80 |
| CHEMBL505915 | GSK-1751853A | IC50 | = | 1585.0 | nM | 5.80 |
| CHEMBL511765 | GSK-2213727A | IC50 | = | 1995.0 | nM | 5.70 |
| CHEMBL461018 | — | IC50 | = | 1995.0 | nM | 5.70 |
| CHEMBL465168 | — | IC50 | = | 1995.0 | nM | 5.70 |
| CHEMBL467136 | — | IC50 | = | 2512.0 | nM | 5.60 |
| CHEMBL516816 | — | IC50 | = | 3162.0 | nM | 5.50 |
| CHEMBL464344 | — | IC50 | = | 3162.0 | nM | 5.50 |
| CHEMBL468619 | — | IC50 | = | 3162.0 | nM | 5.50 |
| CHEMBL465374 | — | IC50 | = | 3891.0 | nM | 5.41 |
| CHEMBL517171 | GSK-1713088A | IC50 | = | 3981.0 | nM | 5.40 |
| CHEMBL461875 | — | IC50 | = | 5011.0 | nM | 5.30 |
| CHEMBL464552 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL516870 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL459538 | — | IC50 | = | 7943.0 | nM | 5.10 |
| CHEMBL465789 | — | IC50 | = | 7943.0 | nM | 5.10 |
| CHEMBL467581 | GSK-2219385A | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL467580 | — | IC50 | = | 10000.0 | nM | 5.00 |