Assay Detail
Binding
CHEMBL1033199
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Ratio of Ki for human dopamine D2 receptor to Ki for human dopamine D4 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 9.21 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084502 | — | — | 1 | 10.30 |
| CHEMBL514590 | — | — | 1 | 10.15 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 10.00 |
| CHEMBL460854 | — | — | 1 | 9.72 |
| CHEMBL210578 | — | — | 1 | 9.52 |
| CHEMBL514591 | — | — | 1 | 9.48 |
| CHEMBL514747 | — | — | 1 | 9.05 |
| CHEMBL456430 | — | — | 1 | 8.99 |
| CHEMBL456429 | — | — | 1 | 8.80 |
| CHEMBL150161 | — | — | 1 | 8.52 |
| CHEMBL460223 | — | — | 1 | 8.29 |
| CHEMBL460644 | — | — | 1 | 7.68 |
| CHEMBL458342 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084502 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL514590 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL460854 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL210578 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL514591 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL514747 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL456430 | — | Ki | = | 1.03 | nM | 8.99 |
| CHEMBL456429 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL150161 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL460223 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL460644 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL458342 | — | Ki | > | 17.0 | nM | - |