Assay Detail
Functional
CHEMBL1033249
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Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.05 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212378 | — | — | 1 | 6.52 |
| CHEMBL455983 | — | — | 1 | 6.52 |
| CHEMBL512379 | — | — | 1 | 6.30 |
| CHEMBL515670 | — | — | 1 | 6.16 |
| CHEMBL456191 | — | — | 1 | 6.10 |
| CHEMBL455984 | — | — | 1 | 5.92 |
| CHEMBL458504 | — | — | 1 | 5.60 |
| CHEMBL446313 | — | — | 1 | 5.31 |
| CHEMBL457236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212378 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL455983 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL512379 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL515670 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL456191 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL455984 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL458504 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL446313 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL457236 | — | IC50 | > | 100000.0 | nM | - |