Assay Detail
Functional
CHEMBL1033544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.37 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417613 | — | — | 1 | 7.11 |
| CHEMBL552497 | — | — | 1 | 7.08 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.00 |
| CHEMBL562154 | — | — | 1 | 6.96 |
| CHEMBL551831 | — | — | 1 | 6.92 |
| CHEMBL562153 | — | — | 1 | 6.85 |
| CHEMBL561291 | — | — | 1 | 6.62 |
| CHEMBL466705 | — | — | 1 | 6.54 |
| CHEMBL557269 | — | — | 1 | 6.44 |
| CHEMBL564556 | — | — | 1 | 6.33 |
| CHEMBL552434 | — | — | 1 | 6.31 |
| CHEMBL539226 | — | — | 1 | 6.30 |
| CHEMBL561693 | — | — | 1 | 6.28 |
| CHEMBL551892 | — | — | 1 | 6.26 |
| CHEMBL561211 | — | — | 1 | 6.25 |
| CHEMBL552089 | — | — | 1 | 6.19 |
| CHEMBL564544 | — | — | 1 | 6.13 |
| CHEMBL561348 | — | — | 1 | 6.05 |
| CHEMBL551832 | — | — | 1 | 6.02 |
| CHEMBL550743 | — | — | 1 | 6.02 |
| CHEMBL563810 | — | — | 1 | 5.92 |
| CHEMBL561818 | — | — | 1 | 5.82 |
| CHEMBL551350 | — | — | 1 | 5.77 |
| CHEMBL550746 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417613 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL552497 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL562154 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL551831 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL562153 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL561291 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL466705 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL557269 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL564556 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL552434 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL539226 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL561693 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL551892 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL561211 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL552089 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL564544 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL561348 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL551832 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL550743 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL563810 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL561818 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL551350 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL550746 | — | EC50 | = | 1700.0 | nM | 5.77 |