Assay Detail
Binding
CHEMBL1033786
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Inhibition of HIV1 integrase strand transfer activity
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 6.52 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203443 | — | — | 1 | 8.05 |
| CHEMBL549549 | — | — | 1 | 7.92 |
| CHEMBL550893 | — | — | 1 | 7.68 |
| CHEMBL379664 | — | — | 1 | 7.62 |
| CHEMBL549546 | — | — | 1 | 7.60 |
| CHEMBL562360 | — | — | 1 | 7.58 |
| CHEMBL561099 | — | — | 1 | 7.51 |
| CHEMBL558481 | — | — | 1 | 7.50 |
| CHEMBL560439 | — | — | 1 | 7.47 |
| CHEMBL563162 | — | — | 1 | 7.46 |
| CHEMBL561100 | — | — | 1 | 7.42 |
| CHEMBL549611 | — | — | 1 | 7.39 |
| CHEMBL559903 | — | — | 1 | 7.37 |
| CHEMBL550895 | — | — | 1 | 7.36 |
| CHEMBL242883 | — | — | 1 | 7.30 |
| CHEMBL549750 | — | — | 1 | 7.30 |
| CHEMBL551437 | — | — | 1 | 7.26 |
| CHEMBL561827 | — | — | 1 | 7.19 |
| CHEMBL560234 | — | — | 1 | 7.16 |
| CHEMBL558286 | — | — | 1 | 7.11 |
| CHEMBL558287 | — | — | 1 | 7.08 |
| CHEMBL550691 | — | — | 1 | 7.08 |
| CHEMBL551235 | — | — | 1 | 6.94 |
| CHEMBL561437 | — | — | 1 | 6.67 |
| CHEMBL549405 | — | — | 1 | 6.60 |
| CHEMBL559705 | — | — | 1 | 6.43 |
| CHEMBL559704 | — | — | 1 | 6.39 |
| CHEMBL561423 | — | — | 1 | 6.30 |
| CHEMBL554504 | — | — | 1 | 6.17 |
| CHEMBL549338 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203443 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL549549 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL550893 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL379664 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL549546 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL562360 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL561099 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL558481 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL560439 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL563162 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL561100 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL549611 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL559903 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL550895 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL549750 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL242883 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL551437 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL561827 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL560234 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL558286 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL558287 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL550691 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL551235 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL561437 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL549405 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL559705 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL559704 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL561423 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL554504 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL549338 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL560960 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL560761 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL549404 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL382680 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL557480 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL561619 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL550080 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL550220 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL565125 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL560836 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL563677 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL549816 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL557891 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL408699 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL563525 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL554722 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL206604 | — | IC50 | = | 8200.0 | nM | - |
| CHEMBL537947 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL560436 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL204656 | ELVITEGRAVIR | IC50 | = | 7200.0 | nM | - |