Assay Detail
Binding
CHEMBL1034147
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Inhibition of chymotrypsin-like activity of yeast 20S proteasome
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.25 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371405 | MARIZOMIB | 3.0 | 1 | 8.70 |
| CHEMBL371634 | SALINOSPORAMIDE B | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371405 | MARIZOMIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL371634 | SALINOSPORAMIDE B | IC50 | = | 16.0 | nM | 7.80 |