Assay Detail
Functional
CHEMBL1034192
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Antileishmanial activity against Leishmania infantum D.SCH amastigotes infected in mouse RAW 264.7 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | RAW |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Leishmanicidal and antiplasmodial activity of constituents of Smirnowia iranica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.16 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.40 |
| CHEMBL2079699 | — | — | 1 | 5.08 |
| CHEMBL498724 | SMIRANICIN | — | 1 | 4.09 |
| CHEMBL498725 | GLYASPERIN H | — | 1 | 4.05 |
| CHEMBL501755 | — | — | 1 | - |
| CHEMBL454996 | — | — | 1 | - |
| CHEMBL489518 | — | — | 1 | - |
| CHEMBL501754 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2079699 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL498724 | SMIRANICIN | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL498725 | GLYASPERIN H | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL501755 | — | IC50 | = | 109000.0 | nM | - |
| CHEMBL454996 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL489518 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL501754 | — | IC50 | > | 800000.0 | nM | - |