Assay Detail
Functional
CHEMBL1034633
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Cytotoxicity against human K562 cells after 48 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive alkaloids from endophytic Aspergillus fumigatus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.58 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 5.92 |
| CHEMBL561363 | — | — | 1 | 5.51 |
| CHEMBL564377 | — | — | 1 | 4.39 |
| CHEMBL36668 | TRYPROSTATIN B | — | 1 | 4.39 |
| CHEMBL289159 | TRYPROSTATIN A | — | 1 | 4.39 |
| CHEMBL463268 | VERRUCULOGEN | — | 1 | 4.39 |
| CHEMBL39346 | DEMETHOXYFUMITREMORGIN C | — | 1 | 4.39 |
| CHEMBL410316 | FUMITREMORGIN | — | 1 | 4.39 |
| CHEMBL541198 | DIMETHYLGLIOTOXIN | — | 1 | 4.39 |
| CHEMBL557488 | FUMITREMORGIN F | — | 1 | 4.39 |
| CHEMBL488302 | SPIROTRYPROSTATIN B | — | 1 | 4.39 |
| CHEMBL549475 | SPIROTRYPROSTATIN A | — | 1 | 4.39 |
| CHEMBL253179 | PSEUROTIN A | — | 1 | 4.39 |
| CHEMBL521059 | 14-NORPSEUROTIN A | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL561363 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL564377 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL36668 | TRYPROSTATIN B | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL289159 | TRYPROSTATIN A | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL463268 | VERRUCULOGEN | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL39346 | DEMETHOXYFUMITREMORGIN C | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL410316 | FUMITREMORGIN | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL541198 | DIMETHYLGLIOTOXIN | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL557488 | FUMITREMORGIN F | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL488302 | SPIROTRYPROSTATIN B | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL549475 | SPIROTRYPROSTATIN A | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL253179 | PSEUROTIN A | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL521059 | 14-NORPSEUROTIN A | IC50 | = | 41000.0 | nM | 4.39 |