Assay Detail
Binding
CHEMBL1034714
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Inhibition of HDAC2 in human HeLa cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.24 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.00 |
| CHEMBL551486 | — | — | 1 | 6.66 |
| CHEMBL539156 | — | — | 1 | 6.51 |
| CHEMBL555906 | — | — | 1 | 6.50 |
| CHEMBL538710 | — | — | 1 | 6.48 |
| CHEMBL561212 | — | — | 1 | 6.35 |
| CHEMBL565140 | — | — | 1 | 6.34 |
| CHEMBL556332 | — | — | 1 | 6.23 |
| CHEMBL541239 | — | — | 1 | 6.14 |
| CHEMBL556532 | — | — | 1 | 6.09 |
| CHEMBL561209 | — | — | 1 | 5.94 |
| CHEMBL538713 | — | — | 1 | 5.92 |
| CHEMBL552750 | — | — | 1 | 5.92 |
| CHEMBL551151 | — | — | 1 | 5.77 |
| CHEMBL557066 | — | — | 1 | 5.73 |
| CHEMBL554573 | — | — | 1 | - |
| CHEMBL538712 | — | — | 1 | - |
| CHEMBL538967 | — | — | 1 | - |
| CHEMBL538364 | — | — | 1 | - |
| CHEMBL562757 | — | — | 1 | - |
| CHEMBL561411 | — | — | 1 | - |
| CHEMBL551549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL551486 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL539156 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL555906 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL538710 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL561212 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL565140 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL556332 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL541239 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL556532 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL561209 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL538713 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL552750 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL551151 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL557066 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL554573 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL538712 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL538967 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL538364 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL562757 | — | IC50 | - | — | - | |
| CHEMBL561411 | — | IC50 | - | — | - | |
| CHEMBL551549 | — | IC50 | - | — | - |