Assay Detail
Functional
CHEMBL1034715
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Antiproliferative activity against human H460 cells after 72 hrs
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.33 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538967 | — | — | 1 | 5.72 |
| CHEMBL539156 | — | — | 1 | 5.66 |
| CHEMBL561212 | — | — | 1 | 5.55 |
| CHEMBL565140 | — | — | 1 | 5.51 |
| CHEMBL552750 | — | — | 1 | 5.48 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.47 |
| CHEMBL561209 | — | — | 1 | 5.43 |
| CHEMBL551486 | — | — | 1 | 5.42 |
| CHEMBL541239 | — | — | 1 | 5.33 |
| CHEMBL556532 | — | — | 1 | 5.27 |
| CHEMBL555906 | — | — | 1 | 5.25 |
| CHEMBL538710 | — | — | 1 | 5.24 |
| CHEMBL556332 | — | — | 1 | 5.22 |
| CHEMBL551549 | — | — | 1 | 5.02 |
| CHEMBL538713 | — | — | 1 | 4.85 |
| CHEMBL551151 | — | — | 1 | 4.82 |
| CHEMBL538364 | — | — | 1 | - |
| CHEMBL557066 | — | — | 1 | - |
| CHEMBL554573 | — | — | 1 | - |
| CHEMBL562757 | — | — | 1 | - |
| CHEMBL538712 | — | — | 1 | - |
| CHEMBL561411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538967 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL539156 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL561212 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL565140 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL552750 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL561209 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL551486 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL541239 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL556532 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL555906 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL538710 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL556332 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL551549 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL538713 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL551151 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL538364 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL557066 | — | IC50 | - | — | - | |
| CHEMBL554573 | — | IC50 | - | — | - | |
| CHEMBL562757 | — | IC50 | - | — | - | |
| CHEMBL538712 | — | IC50 | - | — | - | |
| CHEMBL561411 | — | IC50 | - | — | - |