Assay Detail
Binding
CHEMBL1034790
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Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New cyclic tetrapeptides from Nonomuraea sp. TA-0426 that inhibit glycine transporter type 1 (GlyT1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.56 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475562 | — | — | 1 | 7.68 |
| CHEMBL451169 | — | — | 1 | 7.06 |
| CHEMBL514318 | — | — | 1 | 6.65 |
| CHEMBL515145 | — | — | 1 | 6.56 |
| CHEMBL474037 | — | — | 1 | 6.35 |
| CHEMBL474038 | — | — | 1 | 6.27 |
| CHEMBL473840 | — | — | 1 | 6.24 |
| CHEMBL475845 | — | — | 1 | 5.65 |
| CHEMBL475216 | — | — | 1 | - |
| CHEMBL180966 | — | — | 1 | - |
| CHEMBL505699 | — | — | 1 | - |
| CHEMBL443885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475562 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL451169 | — | IC50 | = | 87.7 | nM | 7.06 |
| CHEMBL514318 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL515145 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL474037 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL474038 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL473840 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL475845 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL475216 | — | IC50 | - | — | - | |
| CHEMBL180966 | — | IC50 | - | — | - | |
| CHEMBL505699 | — | IC50 | - | — | - | |
| CHEMBL443885 | — | IC50 | - | — | - |