Assay Detail
Binding
CHEMBL1034822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli DNA topoisomerase 4 subunit B ParE assessed as inorganic phosphate release by malachite green complex formation assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.06 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 5.88 |
| CHEMBL487851 | — | — | 1 | 5.46 |
| CHEMBL473810 | — | — | 1 | 4.96 |
| CHEMBL515259 | — | — | 1 | 4.60 |
| CHEMBL474194 | — | — | 1 | 4.40 |
| CHEMBL481498 | — | — | 1 | - |
| CHEMBL446903 | — | — | 1 | - |
| CHEMBL481497 | — | — | 1 | - |
| CHEMBL475773 | — | — | 1 | - |
| CHEMBL474605 | — | — | 1 | - |
| CHEMBL474604 | — | — | 1 | - |
| CHEMBL473423 | — | — | 1 | - |
| CHEMBL481904 | — | — | 1 | - |
| CHEMBL481903 | — | — | 1 | - |
| CHEMBL481734 | — | — | 1 | - |
| CHEMBL481733 | — | — | 1 | - |
| CHEMBL454442 | — | — | 1 | - |
| CHEMBL514638 | — | — | 1 | - |
| CHEMBL475175 | — | — | 1 | - |
| CHEMBL475174 | — | — | 1 | - |
| CHEMBL475173 | — | — | 1 | - |
| CHEMBL475172 | — | — | 1 | - |
| CHEMBL474986 | — | — | 1 | - |
| CHEMBL443886 | — | — | 1 | - |
| CHEMBL473811 | — | — | 1 | - |
| CHEMBL473644 | — | — | 1 | - |
| CHEMBL503393 | — | — | 1 | - |
| CHEMBL471970 | — | — | 1 | - |
| CHEMBL443651 | — | — | 1 | - |
| CHEMBL511662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36506 | NOVOBIOCIN | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL487851 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL473810 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL515259 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL474194 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL481498 | — | IC50 | - | — | - | |
| CHEMBL480736 | — | IC50 | = | 145000.0 | nM | - |
| CHEMBL481497 | — | IC50 | - | — | - | |
| CHEMBL475773 | — | IC50 | - | — | - | |
| CHEMBL474605 | — | IC50 | - | — | - | |
| CHEMBL474604 | — | IC50 | - | — | - | |
| CHEMBL473423 | — | IC50 | - | — | - | |
| CHEMBL481904 | — | IC50 | - | — | - | |
| CHEMBL481903 | — | IC50 | - | — | - | |
| CHEMBL481734 | — | IC50 | - | — | - | |
| CHEMBL481733 | — | IC50 | - | — | - | |
| CHEMBL454442 | — | IC50 | - | — | - | |
| CHEMBL446903 | — | IC50 | - | — | - | |
| CHEMBL514638 | — | IC50 | - | — | - | |
| CHEMBL475175 | — | IC50 | - | — | - | |
| CHEMBL475174 | — | IC50 | - | — | - | |
| CHEMBL475173 | — | IC50 | - | — | - | |
| CHEMBL475172 | — | IC50 | - | — | - | |
| CHEMBL474986 | — | IC50 | - | — | - | |
| CHEMBL443886 | — | IC50 | - | — | - | |
| CHEMBL473811 | — | IC50 | - | — | - | |
| CHEMBL473644 | — | IC50 | - | — | - | |
| CHEMBL503393 | — | IC50 | - | — | - | |
| CHEMBL471970 | — | IC50 | - | — | - | |
| CHEMBL443651 | — | IC50 | - | — | - | |
| CHEMBL511662 | — | IC50 | - | — | - |