Assay Detail
Binding
CHEMBL1034865
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Inhibition of Mycobacterium tuberculosis HisG assessed as phosphoribosyl ATP production by spectrophotometry
15
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP phosphoribosyltransferase (CHEMBL6086) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.09 | 5.40 |
| Ki | 4 | 4.98 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL459933 | — | — | 2 | 5.70 |
| CHEMBL459306 | — | — | 2 | 5.70 |
| CHEMBL451611 | — | — | 1 | 5.26 |
| CHEMBL518011 | — | — | 1 | 5.00 |
| CHEMBL459510 | — | — | 1 | 5.00 |
| CHEMBL523351 | — | — | 1 | 4.92 |
| CHEMBL493484 | — | — | 1 | 4.86 |
| CHEMBL75967 | PENTACHLOROPHENOL | — | 1 | 4.30 |
| CHEMBL1466 | DICUMAROL | 4.0 | 1 | 4.22 |
| CHEMBL461642 | — | — | 1 | - |
| CHEMBL461201 | — | — | 1 | - |
| CHEMBL493482 | — | — | 1 | - |
| CHEMBL491074 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL459933 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL459306 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL459933 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL451611 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL459306 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL518011 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL459510 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL523351 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL493484 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL75967 | PENTACHLOROPHENOL | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL1466 | DICUMAROL | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL461642 | — | IC50 | - | — | - | |
| CHEMBL461201 | — | IC50 | - | — | - | |
| CHEMBL493482 | — | IC50 | - | — | - | |
| CHEMBL491074 | — | IC50 | - | — | - |