Assay Detail
Functional
CHEMBL1035402
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Antiproliferative activity against human A549 cells after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.63 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554564 | — | — | 1 | 9.04 |
| CHEMBL329993 | EPOTHILONE A | — | 1 | 8.66 |
| CHEMBL540728 | — | — | 1 | 8.54 |
| CHEMBL558945 | — | — | 1 | 7.79 |
| CHEMBL555516 | — | — | 1 | 6.42 |
| CHEMBL554607 | — | — | 1 | 5.31 |
| CHEMBL539394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554564 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL329993 | EPOTHILONE A | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL540728 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL558945 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL555516 | — | IC50 | = | 378.5 | nM | 6.42 |
| CHEMBL554607 | — | IC50 | = | 4873.0 | nM | 5.31 |
| CHEMBL539394 | — | IC50 | > | 10000.0 | nM | - |