Assay Detail
Functional
CHEMBL1035403
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Antiproliferative activity against human MCF7 cells after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.62 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554564 | — | — | 1 | 8.89 |
| CHEMBL540728 | — | — | 1 | 8.72 |
| CHEMBL329993 | EPOTHILONE A | — | 1 | 8.59 |
| CHEMBL558945 | — | — | 1 | 7.72 |
| CHEMBL555516 | — | — | 1 | 6.53 |
| CHEMBL554607 | — | — | 1 | 5.29 |
| CHEMBL539394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554564 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL540728 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL329993 | EPOTHILONE A | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL558945 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL555516 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL554607 | — | IC50 | = | 5144.0 | nM | 5.29 |
| CHEMBL539394 | — | IC50 | > | 10000.0 | nM | - |