Assay Detail
Binding
CHEMBL1035595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.91 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130200 | — | — | 1 | 6.43 |
| CHEMBL557892 | — | — | 1 | 6.24 |
| CHEMBL571668 | — | — | 1 | 6.19 |
| CHEMBL539380 | — | — | 1 | 6.12 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.92 |
| CHEMBL550284 | — | — | 1 | 4.57 |
| CHEMBL562621 | — | — | 1 | - |
| CHEMBL550349 | — | — | 1 | - |
| CHEMBL561765 | — | — | 1 | - |
| CHEMBL564802 | — | — | 1 | - |
| CHEMBL560501 | — | — | 1 | - |
| CHEMBL561629 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130200 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL557892 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL571668 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL539380 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL550284 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL562621 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL550349 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL561765 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL564802 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL560501 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL561629 | — | IC50 | > | 40000.0 | nM | - |