Assay Detail
Binding
CHEMBL1035690
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Inhibition of human cloned wild type BRAF by ELISA-based MEK phosphorylation assay
33
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of BRAF inhibitors through in silico screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.91 | 5.76 |
| Ki | 2 | 8.61 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477989 | SB590885 | — | 1 | 9.80 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.42 |
| CHEMBL460137 | — | — | 1 | 5.76 |
| CHEMBL454028 | — | — | 1 | 5.68 |
| CHEMBL461421 | — | — | 1 | 5.43 |
| CHEMBL462473 | — | — | 1 | 5.34 |
| CHEMBL460136 | — | — | 1 | 4.96 |
| CHEMBL517286 | — | — | 1 | 4.96 |
| CHEMBL459514 | — | — | 1 | 4.95 |
| CHEMBL459935 | — | — | 1 | 4.76 |
| CHEMBL516963 | — | — | 1 | 4.53 |
| CHEMBL459931 | — | — | 1 | 4.52 |
| CHEMBL516644 | — | — | 1 | 4.43 |
| CHEMBL518187 | — | — | 1 | 4.24 |
| CHEMBL518163 | — | — | 1 | 4.24 |
| CHEMBL459714 | — | — | 1 | - |
| CHEMBL459500 | — | — | 1 | - |
| CHEMBL460344 | — | — | 1 | - |
| CHEMBL516808 | — | — | 1 | - |
| CHEMBL509283 | — | — | 1 | - |
| CHEMBL461621 | — | — | 1 | - |
| CHEMBL516494 | — | — | 1 | - |
| CHEMBL462280 | — | — | 1 | - |
| CHEMBL462279 | — | — | 1 | - |
| CHEMBL462071 | — | — | 1 | - |
| CHEMBL516655 | — | — | 1 | - |
| CHEMBL459736 | — | — | 1 | - |
| CHEMBL516807 | — | — | 1 | - |
| CHEMBL502945 | — | — | 1 | - |
| CHEMBL459515 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477989 | SB590885 | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL1336 | SORAFENIB | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL460137 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL454028 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL461421 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL462473 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL460136 | — | IC50 | = | 10910.0 | nM | 4.96 |
| CHEMBL517286 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL459514 | — | IC50 | = | 11360.0 | nM | 4.95 |
| CHEMBL459935 | — | IC50 | = | 17360.0 | nM | 4.76 |
| CHEMBL516963 | — | IC50 | = | 29420.0 | nM | 4.53 |
| CHEMBL459931 | — | IC50 | = | 30110.0 | nM | 4.52 |
| CHEMBL516644 | — | IC50 | = | 37480.0 | nM | 4.43 |
| CHEMBL518187 | — | IC50 | = | 57710.0 | nM | 4.24 |
| CHEMBL518163 | — | IC50 | = | 57890.0 | nM | 4.24 |
| CHEMBL459936 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL462046 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL459715 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL459714 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL459500 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL460344 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL516808 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL509283 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL461621 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL516494 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL462280 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL462279 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL462071 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL516655 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL459736 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL516807 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL502945 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL459515 | — | IC50 | > | 100000.0 | nM | - |