Assay Detail
Binding
CHEMBL1036059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain CaM-dependent PDE assessed as inorganic phosphate release in presence of bovine brain calmodulin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Spasmolytic effects, mode of action, and structure-activity relationships of stilbenoids from Nidema boothii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.96 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513538 | NIDEMONE | — | 1 | 5.50 |
| CHEMBL219553 | GIGANTOL | — | 1 | 5.16 |
| CHEMBL426871 | — | — | 1 | 5.05 |
| CHEMBL448371 | — | — | 1 | 5.00 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.99 |
| CHEMBL472431 | EPHEMERANTHOQUINONE | — | 1 | 4.96 |
| CHEMBL450788 | BATATASIN III | — | 1 | 4.88 |
| CHEMBL447998 | — | — | 1 | 4.67 |
| CHEMBL228120 | DIHYDROPINOSYLVIN | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513538 | NIDEMONE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL219553 | GIGANTOL | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL426871 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL448371 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL472431 | EPHEMERANTHOQUINONE | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL450788 | BATATASIN III | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL447998 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL228120 | DIHYDROPINOSYLVIN | IC50 | = | 36600.0 | nM | 4.44 |