Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1036417

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to adenosine A2B receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Adenosine receptor A2b (CHEMBL255)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.
Gillespie RJ, Bamford SJ, Gaur S, Jordan AM, Lerpiniere J, Mansell HL, Stratton GC.
Bioorg Med Chem Lett (2009) 19 : 2664 -2667
PubMed 19362836 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.36 7.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL557084 1 7.17
CHEMBL549477 1 6.92
CHEMBL560904 1 6.86
CHEMBL556083 1 6.81
CHEMBL554623 1 6.74
CHEMBL553449 1 6.40
CHEMBL551373 1 6.35
CHEMBL564473 1 6.34
CHEMBL549885 1 6.12
CHEMBL538629 1 6.07
CHEMBL551368 1 6.04
CHEMBL550636 1 6.03
CHEMBL557696 1 5.91
CHEMBL571672 1 5.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL557084 Ki = 67.0 nM 7.17
CHEMBL549477 Ki = 121.0 nM 6.92
CHEMBL560904 Ki = 137.0 nM 6.86
CHEMBL556083 Ki = 156.0 nM 6.81
CHEMBL554623 Ki = 184.0 nM 6.74
CHEMBL553449 Ki = 402.0 nM 6.40
CHEMBL551373 Ki = 444.0 nM 6.35
CHEMBL564473 Ki = 460.0 nM 6.34
CHEMBL549885 Ki = 754.0 nM 6.12
CHEMBL538629 Ki = 858.0 nM 6.07
CHEMBL551368 Ki = 917.0 nM 6.04
CHEMBL550636 Ki = 924.0 nM 6.03
CHEMBL557696 Ki = 1240.0 nM 5.91
CHEMBL571672 Ki = 5875.0 nM 5.23