Assay Detail
Binding
CHEMBL1036479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in bovine polymorphonuclear leucocytes assessed as formation of LTB4 by HPLC method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.35 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | 6.75 |
| CHEMBL57062 | — | — | 1 | 6.75 |
| CHEMBL560897 | — | — | 1 | 6.64 |
| CHEMBL563280 | — | — | 1 | 6.60 |
| CHEMBL550894 | — | — | 1 | 6.58 |
| CHEMBL565159 | — | — | 1 | 6.51 |
| CHEMBL564318 | — | — | 1 | 6.30 |
| CHEMBL292239 | — | — | 1 | 5.82 |
| CHEMBL294159 | — | — | 1 | 5.80 |
| CHEMBL550489 | — | — | 1 | 5.72 |
| CHEMBL29097 | — | — | 1 | - |
| CHEMBL182032 | — | — | 1 | - |
| CHEMBL549341 | — | — | 1 | - |
| CHEMBL561824 | — | — | 1 | - |
| CHEMBL560898 | — | — | 1 | - |
| CHEMBL551236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300982 | LICOFELONE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL57062 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL560897 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL563280 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL550894 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL565159 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL564318 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL292239 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL294159 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL550489 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL29097 | — | IC50 | - | — | - | |
| CHEMBL182032 | — | IC50 | - | — | - | |
| CHEMBL549341 | — | IC50 | - | — | - | |
| CHEMBL561824 | — | IC50 | - | — | - | |
| CHEMBL560898 | — | IC50 | - | — | - | |
| CHEMBL551236 | — | IC50 | - | — | - |