Assay Detail
Functional
CHEMBL1036670
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Antiprotozoal activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 72 hrs by [3H]hypoxanthine uptake
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.01 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215692 | — | — | 1 | 9.00 |
| CHEMBL457986 | — | — | 1 | 8.77 |
| CHEMBL458214 | — | — | 1 | 8.72 |
| CHEMBL467401 | — | — | 1 | 8.59 |
| CHEMBL446515 | — | — | 1 | 8.54 |
| CHEMBL508828 | — | — | 1 | 8.35 |
| CHEMBL456688 | — | — | 1 | 8.15 |
| CHEMBL456899 | — | — | 1 | 8.05 |
| CHEMBL515509 | — | — | 1 | 7.85 |
| CHEMBL459062 | — | — | 1 | 7.57 |
| CHEMBL458215 | — | — | 1 | 7.27 |
| CHEMBL458213 | — | — | 1 | 6.82 |
| CHEMBL468965 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215692 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL457986 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL458214 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL467401 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL446515 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL508828 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL456688 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL456899 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL515509 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL459062 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL458215 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL458213 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL468965 | — | IC50 | = | 393.0 | nM | 6.41 |