Assay Detail
Binding
CHEMBL1036745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.11 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 8.39 |
| CHEMBL446734 | — | — | 1 | 8.04 |
| CHEMBL457423 | — | — | 1 | 7.79 |
| CHEMBL504429 | — | — | 1 | 7.55 |
| CHEMBL457424 | — | — | 1 | 6.41 |
| CHEMBL452354 | — | — | 1 | 6.05 |
| CHEMBL457069 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL446734 | — | IC50 | = | 9.03 | nM | 8.04 |
| CHEMBL457423 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL504429 | — | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL457424 | — | IC50 | = | 388.2 | nM | 6.41 |
| CHEMBL452354 | — | IC50 | = | 883.1 | nM | 6.05 |
| CHEMBL457069 | — | IC50 | = | 3069.0 | nM | 5.51 |