Assay Detail
Binding
CHEMBL1036935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of ethidium bromide from calf thymus DNA by fluorescence assay
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.29 | 7.03 |
| Kapp | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583072 | — | — | 2 | 7.03 |
| CHEMBL583073 | — | — | 2 | 6.91 |
| CHEMBL43482 | MITONAFIDE | 2.0 | 2 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583072 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL583073 | — | EC50 | = | 122.0 | nM | 6.91 |
| CHEMBL43482 | MITONAFIDE | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL43482 | MITONAFIDE | Kapp | = | 2.2 | 10'6/M | - |
| CHEMBL583072 | — | Kapp | = | 2.72 | 10'8/M | - |
| CHEMBL583073 | — | Kapp | = | 2.07 | 10'8/M | - |