Assay Detail
Binding
CHEMBL1037161
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Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIA
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.80 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.95 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 5.60 |
| CHEMBL571199 | NEOLIGNAN 9-NOR-7,8-DEHYDRO-ISOLICARIN B | — | 1 | 5.48 |
| CHEMBL570290 | NECTAMAZIN C | — | 1 | 5.17 |
| CHEMBL571617 | OCOPHYLLALS B | — | 1 | 4.90 |
| CHEMBL571616 | OCOPHYLLALS A | — | 1 | 4.78 |
| CHEMBL578403 | (-)-LICARIN B | — | 1 | 4.59 |
| CHEMBL571195 | ACUMINATIN | — | 1 | 4.54 |
| CHEMBL463526 | LICARIN A | — | 1 | 4.49 |
| CHEMBL259386 | LICARINE B | — | 1 | 4.28 |
| CHEMBL585912 | MACROPHYLLIN B | — | 1 | 4.18 |
| CHEMBL259731 | LICARINE A | — | 1 | 4.18 |
| CHEMBL558110 | CINERIN D | — | 1 | 4.04 |
| CHEMBL578402 | LILIFLOL A | — | 1 | 4.01 |
| CHEMBL570981 | CINERIN B | — | 1 | - |
| CHEMBL561053 | CINERIN C | — | 1 | - |
| CHEMBL296958 | KADSURENONE | — | 1 | - |
| CHEMBL571196 | (+)-DENUDATIN B | — | 1 | - |
| CHEMBL570291 | MIRANDIN A | — | 1 | - |
| CHEMBL585723 | CINERIN A | — | 1 | - |
| CHEMBL570978 | — | — | 1 | - |
| CHEMBL584539 | 4'-OXO-MACROPHYLLIN B | — | 1 | - |
| CHEMBL571615 | KADSURENIN C | — | 1 | - |
| CHEMBL571892 | NECTAMAZIN B | — | 2 | - |
| CHEMBL570318 | OCOPHYLOL C | — | 1 | - |
| CHEMBL583036 | OCOPHYLOL B | — | 1 | - |
| CHEMBL585724 | OCOPHYLOL A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL25 | ASPIRIN | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL571199 | NEOLIGNAN 9-NOR-7,8-DEHYDRO-ISOLICARIN B | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL570290 | NECTAMAZIN C | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL571617 | OCOPHYLLALS B | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL571616 | OCOPHYLLALS A | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL578403 | (-)-LICARIN B | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL571195 | ACUMINATIN | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL463526 | LICARIN A | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL259386 | LICARINE B | IC50 | = | 52100.0 | nM | 4.28 |
| CHEMBL585912 | MACROPHYLLIN B | IC50 | = | 65400.0 | nM | 4.18 |
| CHEMBL259731 | LICARINE A | IC50 | = | 66400.0 | nM | 4.18 |
| CHEMBL558110 | CINERIN D | IC50 | = | 92100.0 | nM | 4.04 |
| CHEMBL578402 | LILIFLOL A | IC50 | = | 98700.0 | nM | 4.01 |
| CHEMBL585724 | OCOPHYLOL A | IC50 | = | 312000.0 | nM | - |
| CHEMBL583036 | OCOPHYLOL B | IC50 | = | 288000.0 | nM | - |
| CHEMBL570318 | OCOPHYLOL C | IC50 | = | 245000.0 | nM | - |
| CHEMBL571892 | NECTAMAZIN B | IC50 | = | 255000.0 | nM | - |
| CHEMBL571892 | NECTAMAZIN B | IC50 | = | 569000.0 | nM | - |
| CHEMBL571615 | KADSURENIN C | IC50 | = | 312000.0 | nM | - |
| CHEMBL584539 | 4'-OXO-MACROPHYLLIN B | IC50 | = | 844000.0 | nM | - |
| CHEMBL570978 | — | IC50 | = | 326000.0 | nM | - |
| CHEMBL585723 | CINERIN A | IC50 | = | 288000.0 | nM | - |
| CHEMBL570291 | MIRANDIN A | IC50 | = | 126000.0 | nM | - |
| CHEMBL571196 | (+)-DENUDATIN B | IC50 | = | 446000.0 | nM | - |
| CHEMBL296958 | KADSURENONE | IC50 | = | 246000.0 | nM | - |
| CHEMBL561053 | CINERIN C | IC50 | = | 356000.0 | nM | - |
| CHEMBL570981 | CINERIN B | IC50 | = | 215000.0 | nM | - |