Assay Detail
Binding
CHEMBL1037893
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Inhibition of human GST-fused ZAP-70 expressed in Sf9 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of potential ZAP-70 kinase inhibitors: pharmacophore design, database screening and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.04 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573483 | — | — | 1 | 8.00 |
| CHEMBL575048 | — | — | 1 | 8.00 |
| CHEMBL573019 | — | — | 1 | 7.40 |
| CHEMBL584570 | — | — | 1 | 7.30 |
| CHEMBL572508 | — | — | 1 | 7.16 |
| CHEMBL574841 | — | — | 1 | 7.10 |
| CHEMBL573484 | — | — | 1 | 7.05 |
| CHEMBL573488 | — | — | 1 | 6.89 |
| CHEMBL584758 | — | — | 1 | 6.77 |
| CHEMBL575052 | — | — | 1 | 6.70 |
| CHEMBL575266 | — | — | 1 | 6.55 |
| CHEMBL584148 | — | — | 1 | 6.52 |
| CHEMBL574839 | — | — | 1 | 6.40 |
| CHEMBL578450 | — | — | 1 | 6.28 |
| CHEMBL573719 | — | — | 1 | 6.16 |
| CHEMBL573959 | — | — | 1 | 5.92 |
| CHEMBL584170 | — | — | 1 | 5.77 |
| CHEMBL583791 | — | — | 1 | 5.75 |
| CHEMBL575252 | — | — | 1 | 5.70 |
| CHEMBL575046 | — | — | 1 | 5.52 |
| CHEMBL574599 | — | — | 1 | 5.52 |
| CHEMBL515757 | — | — | 1 | 5.28 |
| CHEMBL475371 | — | — | 1 | 5.19 |
| CHEMBL572562 | — | — | 1 | 5.14 |
| CHEMBL500086 | — | — | 1 | 5.08 |
| CHEMBL574385 | — | — | 1 | 5.00 |
| CHEMBL472590 | — | — | 1 | 4.88 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 4.68 |
| CHEMBL344319 | — | — | 1 | 4.60 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573483 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL575048 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL573019 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL584570 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL572508 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL574841 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL573484 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL573488 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL584758 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL575052 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL575266 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL584148 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL574839 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL578450 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL573719 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL573959 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL584170 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL583791 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL575252 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL575046 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL574599 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL515757 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL475371 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL572562 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL500086 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL574385 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL472590 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL344319 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL573026 | — | IC50 | = | 50000.0 | nM | 4.30 |