Assay Detail
Functional
CHEMBL1037942
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Cytotoxicity against human HeLa cells by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.94 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | 2.0 | 1 | 9.37 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.29 |
| CHEMBL330407 | — | — | 1 | 9.28 |
| CHEMBL572284 | OMBRABULIN | 3.0 | 1 | 9.14 |
| CHEMBL585539 | — | — | 1 | 8.43 |
| CHEMBL578405 | — | — | 1 | 7.55 |
| CHEMBL570756 | — | — | 1 | 7.50 |
| CHEMBL576300 | — | — | 1 | 7.39 |
| CHEMBL577111 | — | — | 1 | 6.71 |
| CHEMBL571189 | — | — | 1 | 6.61 |
| CHEMBL585161 | — | — | 1 | 6.43 |
| CHEMBL584096 | — | — | 1 | 6.37 |
| CHEMBL572296 | — | — | 1 | 5.93 |
| CHEMBL358424 | — | — | 1 | 5.81 |
| CHEMBL570970 | — | — | 1 | 5.00 |
| CHEMBL571106 | — | — | 1 | 4.99 |
| CHEMBL571891 | — | — | 1 | 4.62 |
| CHEMBL570063 | — | — | 1 | 4.57 |
| CHEMBL570975 | — | — | 1 | - |
| CHEMBL578214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL330407 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL572284 | OMBRABULIN | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL585539 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL578405 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL570756 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL576300 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL577111 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL571189 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL585161 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL584096 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL572296 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL358424 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL570970 | — | IC50 | = | 10070.0 | nM | 5.00 |
| CHEMBL571106 | — | IC50 | = | 10170.0 | nM | 4.99 |
| CHEMBL571891 | — | IC50 | = | 23960.0 | nM | 4.62 |
| CHEMBL570063 | — | IC50 | = | 26810.0 | nM | 4.57 |
| CHEMBL570975 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL578214 | — | IC50 | > | 30000.0 | nM | - |