Assay Detail
Functional
CHEMBL1037943
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Cytotoxicity against human MCF7 cells by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.58 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | 2.0 | 1 | 8.70 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.62 |
| CHEMBL572284 | OMBRABULIN | 3.0 | 1 | 8.51 |
| CHEMBL330407 | — | — | 1 | 8.46 |
| CHEMBL585539 | — | — | 1 | 7.60 |
| CHEMBL570756 | — | — | 1 | 7.20 |
| CHEMBL578405 | — | — | 1 | 6.99 |
| CHEMBL576300 | — | — | 1 | 6.67 |
| CHEMBL577111 | — | — | 1 | 6.57 |
| CHEMBL585161 | — | — | 1 | 6.53 |
| CHEMBL584096 | — | — | 1 | 6.17 |
| CHEMBL571189 | — | — | 1 | 5.93 |
| CHEMBL358424 | — | — | 1 | 5.79 |
| CHEMBL572296 | — | — | 1 | 5.42 |
| CHEMBL571106 | — | — | 1 | 4.97 |
| CHEMBL570970 | — | — | 1 | 4.93 |
| CHEMBL571891 | — | — | 1 | 4.85 |
| CHEMBL570063 | — | — | 1 | 4.59 |
| CHEMBL570975 | — | — | 1 | - |
| CHEMBL578214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL572284 | OMBRABULIN | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL330407 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL585539 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL570756 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL578405 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL576300 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL577111 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL585161 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL584096 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL571189 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL358424 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL572296 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL571106 | — | IC50 | = | 10770.0 | nM | 4.97 |
| CHEMBL570970 | — | IC50 | = | 11840.0 | nM | 4.93 |
| CHEMBL571891 | — | IC50 | = | 14010.0 | nM | 4.85 |
| CHEMBL570063 | — | IC50 | = | 25630.0 | nM | 4.59 |
| CHEMBL570975 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL578214 | — | IC50 | > | 30000.0 | nM | - |