Assay Detail
Functional
CHEMBL1038185
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Inhibition of glucose-induced insulin secretion in rat pancreatic islets assessed as residual insulin release
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pancreatic islet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.48 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571345 | — | — | 1 | 6.64 |
| CHEMBL318931 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571345 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL318931 | — | IC50 | = | 480.0 | nM | 6.32 |