Assay Detail
Binding
CHEMBL1038445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amyloid beta (1-42) aggregation by thioflavin T competition binding experiment
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Push-pull benzothiazole derivatives as probes for detecting beta-amyloid plaques in Alzheimer's brains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.68 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594574 | — | — | 1 | 6.96 |
| CHEMBL594555 | — | — | 1 | 6.92 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594574 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL594555 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | IC50 | = | 670.0 | nM | 6.17 |