Assay Detail
Functional
CHEMBL1038726
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Vascular disrupting activity in HUVEC assessed as change in cell morphology with detachment form substrate after 1 hr by crystal violet staining-based inverted light microscopy
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Vascular disrupting activity of tubulin-binding 1,5-diaryl-1H-imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.02 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.00 |
| CHEMBL582989 | — | — | 1 | 7.40 |
| CHEMBL583618 | — | — | 1 | 6.38 |
| CHEMBL566542 | — | — | 1 | 6.02 |
| CHEMBL376684 | — | — | 1 | 5.18 |
| CHEMBL376683 | — | — | 1 | 4.76 |
| CHEMBL221473 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL582989 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL583618 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL566542 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL376684 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL376683 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL221473 | — | IC50 | = | 41500.0 | nM | 4.38 |