Assay Detail
Binding
CHEMBL1038855
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Displacement of [3H]spiperone from human dopamine D4 receptor expressed in CHO cells by scintillation counting
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.13 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201170 | — | — | 1 | 7.95 |
| CHEMBL380330 | — | — | 1 | 7.36 |
| CHEMBL596448 | — | — | 1 | 5.59 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 5.43 |
| CHEMBL593897 | — | — | 1 | 5.29 |
| CHEMBL594127 | — | — | 1 | 5.18 |
| CHEMBL593395 | — | — | 1 | - |
| CHEMBL593626 | — | — | 1 | - |
| CHEMBL593394 | — | — | 1 | - |
| CHEMBL595720 | — | — | 1 | - |
| CHEMBL594557 | — | — | 1 | - |
| CHEMBL594789 | — | — | 1 | - |
| CHEMBL596179 | — | — | 1 | - |
| CHEMBL610449 | — | — | 2 | - |
| CHEMBL594798 | — | — | 1 | - |
| CHEMBL594799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201170 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL380330 | — | Ki | = | 43.4 | nM | 7.36 |
| CHEMBL596448 | — | Ki | = | 2565.0 | nM | 5.59 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 3748.0 | nM | 5.43 |
| CHEMBL593897 | — | Ki | = | 5092.0 | nM | 5.29 |
| CHEMBL594127 | — | Ki | = | 6644.0 | nM | 5.18 |
| CHEMBL593626 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL593394 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL593395 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL594557 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL594789 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL596179 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL610449 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL610449 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL594798 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL594799 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL595720 | — | Ki | > | 10000.0 | nM | - |