Assay Detail
Binding
CHEMBL1038861
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Displacement of [3H]spiperone from rat dopamine D3 receptor expressed in CHO cells by scintillation counting
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.15 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 7.52 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 170.0 | nM | 6.77 |