Assay Detail
Binding
CHEMBL1038903
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Inhibition of human DHFR in presence of saturating levels of NADPH and DHFA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.79 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606039 | — | — | 1 | 5.72 |
| CHEMBL603198 | — | — | 1 | 5.30 |
| CHEMBL595757 | — | — | 1 | 5.29 |
| CHEMBL594810 | — | — | 1 | 5.20 |
| CHEMBL603849 | — | — | 1 | 5.06 |
| CHEMBL594320 | — | — | 1 | 4.99 |
| CHEMBL595497 | — | — | 1 | 4.91 |
| CHEMBL610181 | — | — | 1 | 4.79 |
| CHEMBL605413 | — | — | 1 | 4.59 |
| CHEMBL604879 | — | — | 1 | 4.48 |
| CHEMBL594339 | — | — | 1 | 4.38 |
| CHEMBL606362 | — | — | 1 | 4.20 |
| CHEMBL593154 | — | — | 1 | 4.06 |
| CHEMBL594790 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606039 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL603198 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL595757 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL594810 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL603849 | — | IC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL594320 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL595497 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL610181 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL605413 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL604879 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL594339 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL606362 | — | IC50 | = | 62700.0 | nM | 4.20 |
| CHEMBL593154 | — | IC50 | = | 86500.0 | nM | 4.06 |
| CHEMBL594790 | — | IC50 | = | 93900.0 | nM | 4.03 |