Assay Detail
Binding
CHEMBL1038905
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Inhibition of mouse DHFR in presence of saturating levels of NADPH and DHFA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.00 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595757 | — | — | 1 | 5.50 |
| CHEMBL603198 | — | — | 1 | 5.43 |
| CHEMBL606039 | — | — | 1 | 5.41 |
| CHEMBL594810 | — | — | 1 | 5.38 |
| CHEMBL603849 | — | — | 1 | 5.38 |
| CHEMBL594320 | — | — | 1 | 5.33 |
| CHEMBL595497 | — | — | 1 | 5.10 |
| CHEMBL610181 | — | — | 1 | 4.84 |
| CHEMBL604879 | — | — | 1 | 4.51 |
| CHEMBL606362 | — | — | 1 | 4.45 |
| CHEMBL594339 | — | — | 1 | 4.35 |
| CHEMBL593154 | — | — | 1 | 4.29 |
| CHEMBL605413 | — | — | 1 | - |
| CHEMBL594790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595757 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL603198 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL606039 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL594810 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL603849 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL594320 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL595497 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL610181 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL604879 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL606362 | — | IC50 | = | 35400.0 | nM | 4.45 |
| CHEMBL594339 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL593154 | — | IC50 | = | 51900.0 | nM | 4.29 |
| CHEMBL605413 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL594790 | — | IC50 | = | 187000.0 | nM | - |