Assay Detail
Binding
CHEMBL1038906
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Inhibition of Pneumocystis carinii DHFR in presence of saturating levels of NADPH and DHFA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.44 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL603198 | — | — | 1 | 4.90 |
| CHEMBL594320 | — | — | 1 | 4.65 |
| CHEMBL604879 | — | — | 1 | 4.59 |
| CHEMBL606039 | — | — | 1 | 4.52 |
| CHEMBL594790 | — | — | 1 | 4.51 |
| CHEMBL594810 | — | — | 1 | 4.47 |
| CHEMBL595497 | — | — | 1 | 4.43 |
| CHEMBL606362 | — | — | 1 | 4.40 |
| CHEMBL605413 | — | — | 1 | 4.37 |
| CHEMBL594339 | — | — | 1 | 4.35 |
| CHEMBL593154 | — | — | 1 | 4.28 |
| CHEMBL595757 | — | — | 1 | 4.27 |
| CHEMBL603849 | — | — | 1 | 4.26 |
| CHEMBL610181 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL603198 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL594320 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL604879 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL606039 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL594790 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL594810 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL595497 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL606362 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL605413 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL594339 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL593154 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL595757 | — | IC50 | = | 53600.0 | nM | 4.27 |
| CHEMBL603849 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL610181 | — | IC50 | = | 77000.0 | nM | 4.11 |