Assay Detail
Binding
CHEMBL1039121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]MCH from human MCH1R expressed in CHO cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.93 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468099 | — | — | 1 | 10.05 |
| CHEMBL568571 | — | — | 1 | 9.92 |
| CHEMBL566880 | — | — | 1 | 9.66 |
| CHEMBL582978 | — | — | 1 | 9.59 |
| CHEMBL582792 | — | — | 1 | 9.46 |
| CHEMBL538425 | — | — | 1 | 9.44 |
| CHEMBL565614 | — | — | 1 | 8.92 |
| CHEMBL585856 | — | — | 1 | 8.89 |
| CHEMBL566257 | — | — | 1 | 8.85 |
| CHEMBL568361 | — | — | 1 | 8.59 |
| CHEMBL593521 | — | — | 1 | 8.46 |
| CHEMBL585509 | — | — | 1 | 8.34 |
| CHEMBL568572 | — | — | 1 | 8.20 |
| CHEMBL585664 | — | — | 1 | 8.17 |
| CHEMBL585880 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468099 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL568571 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL566880 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL582978 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL582792 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL538425 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL565614 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL585856 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL566257 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL568361 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL593521 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL585509 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL568572 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL585664 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL585880 | — | IC50 | = | 45.0 | nM | 7.35 |