Assay Detail
Binding
CHEMBL1039372
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Inhibition of trypsin-activated human recombinant renin
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of orally bioavailable alkyl amine renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.52 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592763 | — | — | 1 | 9.74 |
| CHEMBL589647 | — | — | 1 | 9.64 |
| CHEMBL496430 | — | — | 1 | 9.33 |
| CHEMBL591342 | — | — | 1 | 9.33 |
| CHEMBL605408 | — | — | 1 | 9.32 |
| CHEMBL591578 | — | — | 1 | 9.32 |
| CHEMBL1639 | ALISKIREN | 4.0 | 1 | 9.28 |
| CHEMBL592765 | — | — | 1 | 9.28 |
| CHEMBL591340 | — | — | 1 | 9.24 |
| CHEMBL592762 | — | — | 1 | 9.23 |
| CHEMBL606238 | — | — | 1 | 9.21 |
| CHEMBL590623 | — | — | 1 | 9.21 |
| CHEMBL590388 | — | — | 1 | 9.21 |
| CHEMBL591105 | — | — | 1 | 9.06 |
| CHEMBL591341 | — | — | 1 | 8.93 |
| CHEMBL589399 | — | — | 1 | 8.89 |
| CHEMBL604248 | — | — | 1 | 8.82 |
| CHEMBL590868 | — | — | 1 | 8.77 |
| CHEMBL591104 | — | — | 1 | 8.68 |
| CHEMBL590866 | — | — | 1 | 8.60 |
| CHEMBL591579 | — | — | 1 | 7.85 |
| CHEMBL608264 | — | — | 1 | 7.77 |
| CHEMBL496416 | — | — | 1 | 7.68 |
| CHEMBL592048 | — | — | 1 | 7.51 |
| CHEMBL497821 | — | — | 1 | 7.40 |
| CHEMBL591813 | — | — | 1 | 7.34 |
| CHEMBL592047 | — | — | 1 | 7.34 |
| CHEMBL606026 | — | — | 1 | 7.24 |
| CHEMBL592284 | — | — | 1 | 6.75 |
| CHEMBL591814 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592763 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL589647 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL496430 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL591342 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL605408 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL591578 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL1639 | ALISKIREN | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL592765 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL591340 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL592762 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL606238 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL590623 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL590388 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL591105 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL591341 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL589399 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL604248 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL590868 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL591104 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL590866 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL591579 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL608264 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL496416 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL592048 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL497821 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL591813 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL592047 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL606026 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL592284 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL591814 | — | IC50 | = | 2260.0 | nM | 5.65 |