Assay Detail
Functional
CHEMBL1039780
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Growth inhibition of human COLO205 cells after 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3',4',5'-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.54 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227766 | — | — | 1 | 5.66 |
| CHEMBL9941 | — | — | 1 | 4.95 |
| CHEMBL593237 | — | — | 1 | 4.89 |
| CHEMBL608862 | — | — | 1 | 4.88 |
| CHEMBL611637 | — | — | 1 | 4.73 |
| CHEMBL17442 | — | — | 1 | 4.72 |
| CHEMBL126617 | — | — | 1 | 4.70 |
| CHEMBL61863 | — | — | 1 | 4.65 |
| CHEMBL594627 | — | — | 1 | 4.65 |
| CHEMBL61998 | — | — | 1 | 4.59 |
| CHEMBL227701 | — | — | 1 | 4.53 |
| CHEMBL227891 | — | — | 1 | 4.38 |
| CHEMBL59351 | — | — | 1 | 4.37 |
| CHEMBL227779 | — | — | 1 | 4.33 |
| CHEMBL487914 | — | — | 1 | 4.31 |
| CHEMBL1224710 | — | — | 1 | 4.16 |
| CHEMBL285901 | — | — | 1 | 4.12 |
| CHEMBL610624 | — | — | 1 | 4.12 |
| CHEMBL594181 | — | — | 1 | 4.08 |
| CHEMBL593463 | — | — | 1 | 4.06 |
| CHEMBL190474 | — | — | 1 | - |
| CHEMBL486273 | — | — | 1 | - |
| CHEMBL611653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227766 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL9941 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL593237 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL608862 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL611637 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL17442 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL126617 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL61863 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL594627 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL61998 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL227701 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL227891 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL59351 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL227779 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL487914 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1224710 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL285901 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL610624 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL594181 | — | IC50 | = | 82500.0 | nM | 4.08 |
| CHEMBL593463 | — | IC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL190474 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL486273 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL611653 | — | IC50 | > | 100000.0 | nM | - |