Assay Detail
Binding
CHEMBL1039900
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Inhibition of HIV reverse transcriptase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.89 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.08 |
| CHEMBL567510 | — | — | 1 | 7.47 |
| CHEMBL577718 | — | — | 1 | 7.40 |
| CHEMBL568575 | — | — | 1 | 7.38 |
| CHEMBL565830 | — | — | 1 | 7.37 |
| CHEMBL576256 | — | — | 1 | 7.13 |
| CHEMBL577271 | — | — | 1 | 7.09 |
| CHEMBL435128 | CAPRAVIRINE | 2.0 | 1 | 7.03 |
| CHEMBL571987 | LERSIVIRINE | 2.0 | 1 | 6.92 |
| CHEMBL567916 | — | — | 1 | 6.89 |
| CHEMBL565829 | — | — | 1 | 6.62 |
| CHEMBL566470 | — | — | 1 | 6.58 |
| CHEMBL567509 | — | — | 1 | 6.51 |
| CHEMBL579031 | — | — | 1 | 6.46 |
| CHEMBL576255 | — | — | 1 | 6.22 |
| CHEMBL577507 | — | — | 1 | 6.05 |
| CHEMBL572207 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL567510 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL577718 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL568575 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL565830 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL576256 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL577271 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL435128 | CAPRAVIRINE | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL571987 | LERSIVIRINE | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL567916 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL565829 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL566470 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL567509 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL579031 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL576255 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL577507 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL572207 | — | IC50 | = | 1000.0 | nM | 6.00 |