Assay Detail
Functional
CHEMBL1040518
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at canine TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.35 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576138 | — | — | 1 | 7.50 |
| CHEMBL575966 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576138 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL575966 | — | EC50 | = | 63.1 | nM | 7.20 |