Assay Detail
Functional
CHEMBL1040884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat CB1 receptor assessed as inhibition of forskolin-induced cAMP production by cell based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.05 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | — | 1 | 8.00 |
| CHEMBL271158 | — | — | 1 | 7.92 |
| CHEMBL262865 | — | — | 1 | 6.61 |
| CHEMBL576706 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL271158 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL262865 | — | EC50 | = | 248.0 | nM | 6.61 |
| CHEMBL576706 | — | EC50 | = | 2077.0 | nM | 5.68 |