Assay Detail
Binding
CHEMBL1041188
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Inhibition of human cytosolic carbonic anhydrase 2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.29 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153094 | DECYL SULFAMATE | — | 1 | 9.15 |
| CHEMBL24261 | OCTYL SULFAMATE | — | 1 | 8.57 |
| CHEMBL182455 | — | — | 1 | 7.84 |
| CHEMBL171476 | — | — | 1 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153094 | DECYL SULFAMATE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL24261 | OCTYL SULFAMATE | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL182455 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL171476 | — | Ki | = | 24.5 | nM | 7.61 |