Assay Detail
Functional
CHEMBL1041640
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Cytotoxicity against human HeLa cells after 72 hrs by XTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.07 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10121 | — | — | 1 | 8.54 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL98983 | — | — | 1 | 8.49 |
| CHEMBL230846 | — | — | 1 | 7.80 |
| CHEMBL611348 | — | — | 1 | 7.77 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 7.52 |
| CHEMBL572527 | — | — | 1 | 7.52 |
| CHEMBL99988 | — | — | 1 | 7.52 |
| CHEMBL593383 | — | — | 1 | 7.52 |
| CHEMBL594988 | — | — | 1 | 7.50 |
| CHEMBL609879 | — | — | 1 | 7.46 |
| CHEMBL230741 | — | — | 1 | 7.46 |
| CHEMBL431388 | — | — | 1 | 7.43 |
| CHEMBL410946 | — | — | 1 | 7.36 |
| CHEMBL593843 | — | — | 1 | 7.22 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.72 |
| CHEMBL595699 | — | — | 1 | 6.70 |
| CHEMBL593370 | — | — | 1 | 6.62 |
| CHEMBL295663 | — | — | 1 | 6.54 |
| CHEMBL595768 | — | — | 1 | 6.52 |
| CHEMBL593356 | — | — | 1 | 6.52 |
| CHEMBL595916 | — | — | 1 | 6.52 |
| CHEMBL573058 | — | — | 1 | 6.35 |
| CHEMBL247386 | — | — | 1 | 5.77 |
| CHEMBL596358 | — | — | 1 | 5.75 |
| CHEMBL608993 | — | — | 1 | 5.60 |
| CHEMBL574632 | — | — | 1 | 5.60 |
| CHEMBL487314 | — | — | 1 | - |
| CHEMBL572820 | — | — | 1 | - |
| CHEMBL247187 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10121 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL98983 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL230846 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL611348 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL572527 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL99988 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL593383 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL594988 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL609879 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL230741 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL431388 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL410946 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL593843 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL595699 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL593370 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL295663 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL595768 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL593356 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL595916 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL573058 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL247386 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL596358 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL608993 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL574632 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL487314 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL572820 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL247187 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL595676 | — | IC50 | > | 1000.0 | nM | - |